• On the contrary Birrel and colleagues observed

  2024-08-14

  

  On the contrary, Birrel and colleagues observed divergent proliferative responses to androgens in different BC cell lines: DHT and mibolerone were found to inhibit the T47-D and ZR-75-1 INCB28060 growth, while the proliferation of MCF-7 cells was increased by both the androgens [53]. It is worth no

• Introduction Lipoxygenases LOXs are key enzymes that catalyz

  2024-08-13

  

  Introduction Lipoxygenases (LOXs) are key enzymes that catalyze the polyunsaturated fatty acids (PUFAs) such as arachidic Iodophenpropit dihydrobromide (AA), linoleic acid (LA) and others unsaturated fatty acids (Brash, 1999). LOXs are expressed in immune, neural, epithelial, tumor cells and other

• br Study approval br Author contributions br Conflicts of

  2024-08-13

  

  Study approval Author contributions Conflicts of interest Acknowledgements This work was supported by grants of the Youth Backbone Program (to Jianming Ying) of Cancer Hospital, CAMS, Beijing, Beijing Hope Run Special Fund of Cancer Foundation of China (LC2015A06) and the National Natura

• br Conclusions br Conflict of interest

  2024-08-13

  

  Conclusions Conflict of interest Introduction Plants often encounter a series of abiotic stresses during the growth process, including high salinity, extreme temperatures and drought (Knight and Knight, 2001). Plants can adapt through ionic and osmotic homeostasis or osmotic adjustment, con

• To understand the kinase selectivity profile of this series

  2024-08-13

  

  To understand the kinase selectivity profile of this series, EZLink NHS-Biotin Kit , as a representative analog from this series, was profiled against 216 purified protein kinases representing the tyrosine and serine/threonine kinase families using an in-house Caliper EZ Reader mobility shift assay

• br Patients and Methods br Results br Discussion Gjerdrum

  2024-08-13

  

  Patients and Methods Results Discussion Gjerdrum et al showed that Axl FDA-approved Drug Library sale is required to maintain the mesenchymal-like invasiveness of metastatic breast carcinoma cells, but Axl knockdown has no effect on the cell proliferation of MDA-MB-231 cells. Mackiewicz et

• Apelin is involved in various physiological functions

  2024-08-12

  

  Apelin is involved in various physiological functions, including UK 356618 contraction (Ashley et al., 2005), vasodilatation (Jia et al., 2007), feeding control (Valle et al., 2008), and metabolic homeostasis (Higuchi et al., 2007, Dray et al., 2008, Attane et al., 2010). Its plasma level is elevat

• In conclusion our data highlight that variable anti oxidativ

  2024-08-12

  

  In conclusion, our data highlight that variable anti-oxidative 3-AP could be released through peptic hydrolysis of CMP fractions. Although casein hydrolysates produced a larger number of peptides (Table 1) with variable antioxidant capacities, all the peptides from whey hydrolysate exhibited higher

• Plant tissues were thought to be natural sources

  2024-08-12

  

  Plant tissues were thought to be natural sources containing different types of antioxidant compounds (tocopherols, ascorbic acid, carotenoids, and phenolic compounds). As a general classification, antioxidants were grouped as vitamins (ascorbic acid, tocopherols), carotenoids (condensed tannins, xan

• Indications that HMGA proteins are

  2024-08-12

  

  Indications that HMGA proteins are involved in regulating the structure and function of large chromatin domains come from the early work of Saitoh and Laemmli [143]. Employing immunolocalization techniques, these workers demonstrated that HMGA1 proteins are co-localized with both histone H1 and the

• br Acknowledgements This study was funded the

  2024-08-12

  

  Acknowledgements This study was funded the Irish Department of Agriculture, Food and the Marine through the research program FIRM/RSF/CoFoRD (Reference: 13 F 462). The authors declare no conflict of interest. Introduction Radiotherapy (RT) is one of the major treatment methods among patients

• Maynard et al demonstrated that serum levels of sFlt

  2024-08-12

  

  Maynard et al. [54] demonstrated that serum levels of sFlt-1 were five times higher in pregnant women with PE than in normotensive women; as a consequence, VEGF and PlGF levels were found to be proportionally reduced in these women [54]. The literature confirms that there is a sharp increase in sFlt

• We have recently begun to demonstrate this concept

  2024-08-12

  

  We have recently begun to demonstrate this concept by reporting a novel class of β-hairpin peptidomimetics, built on a piperidine-pyrrolidine semi-rigid β-turn inducer [12] and bearing two recognition pentapeptide sequences, designed on oligomeric and fibril structures of Aβ1-42 (compound 1, Fig. 1)

• br Introduction It is well known that when epithelial

  2024-08-12

  

  Introduction It is well known that when epithelial cells are deprived of anchorage, they undergo detachment-induced apoptosis, also known as anoikis. Cancer cells, by contrast, are able to suppress anoikis and survive under anchorage -independent conditions in the circulating system, which is tho

• br Introduction There are greater than five

  2024-08-12

  

  Introduction There are greater than five million Americans living with Alzheimer's dementia and more than 35 million people worldwide [1], and without a way to stop or slow the progression, there will be nearly a tripling of individuals affected by 2050 (13.8 million) [1]. The urgency to develop

15479 records 112/1032 page Previous Next First page 上5页 111112113114115 下5页 Last page