• Insulin de sensitization has been

  2022-08-18

  

  Insulin de-sensitization has been observed in the brains of people with AD [51], [52], [53] and we previously demonstrated that the GLP-1 analogue liraglutide was able to reverse this [54]. Importantly, E64 insulin de-sensitization correlates well with cognitive decline [15], [55] and with tau prot

• In mammals a major physiological role of the

  2022-08-18

  

  In mammals, a major physiological role of the GHSR gene appears to be in regulating food intake and energy homeostasis by partaking in the neuronal mechanisms involving neuropeptide Y and agouti-related protein (Nakazato et al., 2001, Chen et al., 2017). In our study, determination of the abundance

• Beta-Lapachone No specific inhibitor of KCC has progressed t

  2022-08-18

  

  No specific inhibitor of KCC has progressed to clinical trials, however, although compounds like H74 were shown to specifically target KCC over the related Na+-K+-2Cl− cotransporter (NKCC) (Ellory et al., 1990). This molecule, or its related analogues, represent compounds of promise. Simple Mg suppl

• One effective approach to fine

  2022-08-18

  

  One effective approach to fine-tuning the lipophilicity profile of FFA1 agonists is to ‘decorate’ the 3-phenylpropahoic Protease Inhibitor Library scaffold with polar heterocyclic moieties. Alternatively, this scaffold could be replaced with heterocyclic isosteres (as in Takeda’s compounds 1,2 and

• Although exhibited high inhibitory activity was found to

  2022-08-18

  

  Although exhibited high inhibitory activity, was found to be metabolically unstable due to the hydrolysis of the phosphate group (data not shown), which prompted us to modify the phosphate moiety of . Comparison of the activities between three compounds bearing no or different spacer groups (, , a

• Histone acetylation is regulated by two groups

  2022-08-17

  

  Histone acetylation is regulated by two groups of enzymes, histone acetyltransferases (HATs) and deacetylases (HDACs), with antagonizing functions (Wang et al., 2009b). Among members of HATs, p300 and CBP are homologous. Both are global transcriptional co-activators (Ogryzko et al., 1996), and play

• The cytotoxicity of these compounds against Hep B cells was

  2022-08-17

  

  The cytotoxicity of these compounds against Hep3B cells was assessed using the MTT assay. As shown in , compounds in series and (except ), which retained the carboxyl at C-17, showed no appreciable cytotoxic activity (IC > 100 μM), whereas compounds in series (except ,) were modestly cytotoxic, i

• Intracellular signaling pathways leading to

  2022-08-17

  

  Intracellular signaling pathways leading to IR injury are initiated by an increase in reactive oxygen species (ROS). This occurs principally at the time of initiation of reperfusion, which is accompanied by the re-admission of oxygen to the ischemic tissue. The resulting cascade of downstream events

• Cut proteins have five evolutionarily conserved

  2022-08-17

  

  Cut proteins have five evolutionarily conserved domains. These include a homeodomain, three Cut repeats, and a coiled coil structure. The cut repeats, called CR1, CR2, and CR3, are composed of 70 amino acids, and, along with the homeodomain, are each capable of binding DNA. Mammalian cut proteins fu

• Aurora kinase B AURKB and

  2022-08-17

  

  Aurora kinase B (AURKB) and haploid cell-specific protein kinase (Haspin) are two well-known participants in N-terminal histone H3 phosphorylations during mitosis. A related role played by these kinases relates to the fact that AURKB is activated by Haspin promoted phosphorylation at T3. Irrespectiv

• Compound C To facilitate the development of novel diagnostic

  2022-08-17

  

  To facilitate the development of novel diagnostic and therapeutic interventions in NASH, a plethora of animal models have been used to identify molecular targets that are involved in the onset and progression of NASH. In view of recent advances in the understanding of the pathogenesis of NASH and pr

• br Materials and methods br Results br Discussion To

  2022-08-17

  

  Materials and methods Results Discussion To the best of our knowledge, the current study presented the first evidence that GPR40, also named FFAR1, played an essential role in bone formation and mediated 51 8 induced osteogenic effect via Wnt/β-catenin signaling. We found that dose–respons

• Ability of D Ala GIP to attenuate the neurobehavioral

  2022-08-17

  

  Ability of D-Ala2GIP to attenuate the neurobehavioral sequelae in QA-induced Huntington's disease model by reduction in lipid peroxidation, restoration of endogenous antioxidants and decreased striatal monoamine levels is of potential interest. Considerable preclinical evidence now exists of the pot

• In single channel studies Zn primarily

  2022-08-16

  

  In single channel studies, Zn2+ primarily inhibits GABA-A receptors through the reduction of channel opening probability (Smart, 1992, Smart et al., 1994). In slice recordings, Zn2+ significantly reduces phasic mIPSC event amplitude and kinetics, as well as desensitization kinetics (Barberis et al.,

• Prion diseases are transmissible and result in fatal neurode

  2022-08-16

  

  Prion diseases are transmissible and result in fatal neurodegenerative disorders, which, similar to AD, also involve the infiltration and activation of mononuclear phagocytes in Sulfaphenazole sale lesions (reviewed in [61]). A 21 amino-acid fragment of the aberrant human prion protein, Prp106–126,

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